This thesis explores how Venice’s Civic Museums could become more accessible and inclusive for autistic people by 2042, reframing accessibility as a strategic question for the city’s future. In a fragile urban ecosystem requiring cultural and social care as much as infrastructural protection, museum accessibility asks whether Venice can remain not only a preserved heritage site, but a living city open to diverse experiences of culture and participation. Grounded in the 2022 ICOM definition of museums as accessible, inclusive and committed to community participation, the project narrows its scope from over 40 Venetian museums and multiple disabilities to two choices: the eleven Civic Museums and autism. The Civic Museums form a representative cultural core, while autism remains under-addressed in accessibility programmes despite its increasing prevalence, linked to earlier screening, diagnostic criteria and greater awareness. The methodology combines desk research, horizon scanning and seventeen strategic interviews with political, cultural, museum, educational, associative and psychological actors. These conversations reveal the decision-making ecosystem around accessibility and highlight barriers and opportunities. Futures Studies provide the long-term framework: not to predict 2042, but to identify directions, obstacles and leverage points. Through Futures Triangle and Futures Cone, the thesis develops three scenarios: preferable, non-preferable and plausible. Ultimately, the thesis transforms an accessibility challenge into a reflection on Venice’s future. It identifies cultural accessibility as strategic for strengthening the relationship between museums, communities and the city. The Civic Museums emerge as cultural welfare infrastructures, where heritage fosters participation and inclusion. Preserving Venice therefore means safeguarding its heritage while ensuring that it continues to generate opportunities for those who inhabit the city and keep it alive